Preheat your oven to 400°F (200°C) and line a baking sheet with parchment paper.

Pat the chicken breasts dry with paper towels.

In a small bowl, mix together salt, pepper, garlic powder, and onion powder. Generously season both sides of each chicken breast with this spice blend.

Create a breading station with three shallow dishes: one with flour, one with beaten eggs mixed with Dijon mustard, and one with crushed pretzels.

Dredge each chicken breast in flour, then dip in the egg mixture, and coat with crushed pretzels.

Place the coated chicken breasts on the prepared baking sheet and bake for 25–30 minutes until golden brown and cooked through.

In a small saucepan over medium heat, combine milk and Dijon mustard, stirring until warm. Gradually whisk in the cheddar cheese until melted and smooth.

Season the sauce with salt and pepper, and serve hot drizzled over the Pretzel Chicken.